Dioflav is a venotropic and a vascular protector. It is used for:
- Treatment of symptoms and signs related to chronic venous insufficiency of the lower extremities: heavy legs and oedema, pain, tiredness.
- Symptomatic treatment of haemorrhoidal crisis.
DO NOT TAKE DIOFLAV
• if you are allergic to the active substance or any of the other ingredients of this medicine (listed in section 6).
WARNINGS AND PRECAUTIONS
Talk to your doctor or pharmacist before taking Dioflav.
VENOUS INSUFFICIENCY
If your condition worsens during treatment, which may be reflected by inflammation of the skin or veins, hardening of the tissue under the skin, intense pain, skin ulcers or atypical symptoms, such as sudden swelling of one or both legs, see your doctor immediately.
Treatment with Dioflav is more beneficial when accompanied by a balanced lifestyle:
• avoid exposure to sunlight and avoid standing for any significant length of time;
• maintain an appropriate weight;
• in some patients, wearing special stockings can improve circulation.
Dioflav will not help reduce swelling in your legs if it is caused by heart, kidney or liver disease.
HAEMORRHOIDAL CRISIS
If you have a haemorrhoidal crisis, you can only take Dioflav for a limited period of 15 days. If the symptoms do not go away within this period, see your doctor.
If your condition worsens during treatment, i.e. if you notice increased bleeding from your anus (rectum) or blood in your stool, or if you are in doubt about haemorrhoid-related bleeding, see your doctor.
Treatment with Dioflav is not a substitute for specific treatment for other anal conditions.
CHILDREN AND ADOLESCENTS
Use in children and adolescents is not recommended.
OTHER MEDICINES AND DIOFLAV
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
DIOFLAV WITH FOOD AND DRINK
You should take Dioflav with meals.
PREGNANCY AND BREASTFEEDING
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
PREGNANCY
As a precautionary measure, it is preferable to avoid the use of Dioflav during pregnancy.
BREASTFEEDING
Breastfeeding is not recommended during treatment, due to insufficient data on the excretion of the product into breast milk.
DRIVING AND OPERATING MACHINERY
Dioflav does not appear to interfere with the ability to drive or use machines. If you experience dizziness, do not drive or use machines.
Always take this medicine exactly as described in this leaflet or as your doctor, pharmacist or nurse has told you. Talk to your doctor, pharmacist or nurse if you have any questions.
ROUTE OF ADMINISTRATION
Dioflav should be taken with meals.
Swallow the tablet with some liquid.
IF YOU TAKE MORE DIOFLAV THAN YOU SHOULD
If you take more Dioflav than you should, contact your doctor or pharmacist immediately. Experience of overdoses with bioflavonoids is limited, but reported symptoms include diarrhoea, nausea, abdominal pain, pruritus and rash.
IF YOU FORGET TO TAKE DIOFLAV
Take your next dose at the usual time. Do not take a double dose to make up for a missed dose.
If you have any further questions on the use of this product, ask your doctor, pharmacist or nurse.
Like all medicines, this medicine can cause undesirable effects, although not everybody gets them.
In order of decreasing frequency, undesirable effects may include:
NERVOUS SYSTEM DISORDERS:
• Rare: dizziness, headache, malaise.
GASTROINTESTINAL DISORDERS:
• Common: diarrhoea, dyspepsia, nausea, vomiting.
• Uncommon: colitis.
• Not known: abdominal pain.
SKIN AND SUBCUTANEOUS TISSUE DISORDERS:
• Rare: rash, pruritus, urticaria.
• Not known: isolated swelling of the face, lips, eyelids.
Very rare: Quincke’s disease.
REPORTING UNDESIRABLE EFFECTS
If you have any undesirable effects, including possible undesirable effects not listed in this leaflet, talk to your doctor, pharmacist or nurse. You can also report undesirable effects directly to INFARMED, I.P. using the contact information indicated below. By reporting undesirable effects, you will help provide more information on the safety of this medicine.
Website: http://www.infarmed.pt/web/infarmed/submissaoram (preferably)
or at the following addresses:
Direção de Gestão do Risco de Medicamentos
Parque da Saúde de Lisboa, Av. Brasil 53
1749-004 Lisbon
Tel: +351 21 798 73 73
Medicine Helpline: 800222444 (free)
Email: farmacovigilancia@infarmed.pt
THE COMPOSITION OF DIOFLAV
- The active substances are bioflavonoids (micronised purified flavonoid fraction). Each 500 mg film-coated tablet contains:
• 90% diosmin, i.e. 450 mg per film-coated tablet,
• 10% flavonoids expressed as hesperidin, i.e. 50 mg per film-coated tablet.
- The other components are:
Core: Microcrystalline cellulose, gelatine, corn starch, magnesium stearate and talc.
Tablet coating: partially hydrolysed polyvinyl alcohol, macrogol/PEG 3350, titanium dioxide (E 171), yellow iron oxide (E 172), red iron oxide (E 172) and talc.
WHAT DIOFLAV LOOKS LIKE AND CONTENTS OF THE PACK
Oblong, brownish-orange film-coated tablet with a groove on each side. The groove is there to make it easier to split and swallow and not to divide into equal doses.
Dioflav is sold in packs of 10, 30, 60 and 120 film-coated tablets in blister strips.
Not all packet sizes may be marketed.
MARKETING AUTHORISATION HOLDER:
Towa Pharmaceutical, S.A.
Av. do Forte, 3, Edif. Suécia IV, Piso 0
2794-093 Carnaxide
Portugal
MANUFACTURER:
ExtractumPharma Co. Ltd.
IV körzet 6
6413 Kunfehértó
Hungary
Detailed and up-to-date information on this medicine is available by scanning the 2D code printed on the packet with a smartphone. The same information is also available at the following URL:
https://www.tolifeotc.com/dioflav
This leaflet was last revised in December 2025.